666 Human skin ethnicity: Contribution of tissue engineering to develop cosmetic ingredients
نویسندگان
چکیده
Recent publications describe various skin disorders in relation with phototypes and aging. The highest (III to VI) are more sensitive acne the appearance of dark spots due inflammation induced by Cutibacterium acnes (previously named Propionibacterium acnes). Ethnic variations dryness aging a lower activity specific enzymes involved maturation lipids stratum corneum were also reported. To observe understand these cutaneous disorders, tissue engineering is perfect tool. Since several years, pigmented epidermis melanocytes derived from have allowed developments vitro models for biological investigations. In this study, developed study associated Treatments biofunctionals natural ingredients further investigated help decrease effects acne, dryness. Hyperpigmentation increase inflammatory cytokines release observed on reconstructed after application C. acnes, pollutant (PM10). Experimental investigations combining molecular biology conducted modify genetically cells order expression targeted proteins. silencing Glucocerebrosidase was performed epidermal barrier function create 3D dryness-like model. Results suggest that treatment Myrciaria Dubia fruit extract helps prevent negative pollutants skin. A hyperpigmentation inflammation, as well an lipid content respective models. These new essential tools investigate ethnic focused ingredients.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.677